Arrowhead Pharmaceuticals

Manager, Commercial Operations

Arrowhead Pharmaceuticals · Pasadena, California, United States
Pasadena, California, United States $120K–$145K Posted 2026-08-06
Salary
$120K–$145K
Type
Full-time
Experience
5+ yr

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Let’s do something amazing together! The Manager of Sales Operations will play an important role in the commercial success of Arrowhead’s leading investigational cardiometabolic medicine – Redemplo (siRNA targeting APOC3).  This product has demonstrated compelling clinical data to date, has been approved by the FDA for Familial Chylomicronemia Syndrome (FCS) and is in late-stage development for the treatment of other grievous conditions, including Severe Hypertriglyceridemia (SHTG).  Over time, the role will expand to cover additional indications and products in the Arrowhead portfolio.

In this key position, you will be supporting Sales Operations for our field-based teams. Reporting to the Director of Commercial Operations and working closely with Sales and Marketing leadership, you will play an important role in the execution of commercial strategy.  Specifically, you will help translate commercial objectives into plan-of-action and goals for the field-based teams, you will support proper sizing, targeting and incentive compensation.  You will also help optimize systems (CRM) and manage logistics including fleet administration and support for the field.

This role is based in Pasadena, California, with an expectation to be in office 5 days a week.

Responsibilities

  • Field Excellence
  • Help set national and regional sales targets in compliance with regulations and in alignment with forecasts. Help align targeting and call planning based on business strategy.
  • Help support the implementation and management of sales compensation plans and incentive programs; adjust as necessary to ensure optimal performance; help automate the targeting and incentive programs.
  • Help manage field alignment, workload calculation, and territory mapping as needed. Adjust as necessary to ensure optimal performance.  Collaborate with sales leadership to ensure optimal field resource allocation.
  • Build infrastructure and improve process
  • In collaboration with IT - support management of all data pertaining to sales and marketing to ensure smooth operations and reporting, including targeting, IC, KPIs, and field sizing. Maintain customer master data. Optimize data sources for sales planning across field teams. Collaborate in the ongoing improvement of the CRM.
  • Support Commercial Operations budget tracking and assist with vendor relationships and day-to-day vendor coordination.
  • Manage the field fleet program: coordinate vehicle assignments, track lease schedules and renewals, liaise with fleet vendors, ensure compliance with company fleet policy, and serve as the primary point of contact for field team fleet-related needs.
  • Create insights
  • Support the definition, development, and regular communication of business KPIs and metrics to various stakeholders.  Collaborate with commercial leadership and business analytics in tracking and reporting on KPIs.

Requirements

  • Bachelor's degree in a business-rated or life sciences field. Strong understanding of the life sciences industry.
  • 5+ years of progressive commercial experience in biotechnology or pharmaceuticals
  • 2+ years of experience in pharmaceutical data/sales operations; including roles such as brand management, data management, sales operations, analytics, forecasting.
  • Strong leadership and communication skills; effective vendor management
  • Ability to work collaboratively in a matrixed, team-based environment, with strong organizational and time management capabilities.
  • You may be required to travel for up to 20% of your time.

Preferred

  • Experience in the cardiometabolic disease space

California pay range
$120,000 — $145,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

California Applicant Privacy Policy

$60K — 10th pctl $230K — 90th pctl
This role’s midpoint $132K vs. market median $125K for Operations roles
~median
market rate
Based on 18,000+ Operations roles with disclosed salary ranges tracked on NewJob.
Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals

Biotechnology · Public · Pasadena, USA

Stage & Valuation
Public · $10.5B
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Operations (32) · BizOps (6) · Engineering (4)
Arrowhead Pharmaceuticals develops medicines that treat intractable diseases by silencing the genes that cause them. The company utilizes its proprietary Targeted RNAi Molecule (TRiM) platform to create RNA interference therapeutics.
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