About this role
At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.
We are looking for a skilled and motivated Senior Research Associate to join our affinity reagent discovery team. In this role, you will be a hands-on contributor to discovery campaigns including affinity reagent selection and characterization — from library panning through functional validation. You will provide both technical depth and the flexibility in a fast-moving, multi-project environment.
Responsibilities
- Execute and optimize phage display panning campaigns to identify and enrich antigen-specific affinity reagent clones
- Perform high-throughput screening and characterization using a variety of techniques, including ELISA, western blot, biolayer interferometry (BLI) and the Nautilus proteomics platform
- Carry out molecular cloning workflows supporting antibody reformatting, expression construct design, and recombinant protein production
- Culture mammalian cells (e.g., HEK293) for transient and stable protein expression
- Contribute to data recording, experiment tracking, and reagent management within a LIMS platform
- Present experimental results clearly and concisely to cross-functional teams
- Author and maintain SOPs, assay protocols, and other controlled documentation
- Take on dynamic task assignments across projects as team priorities evolve — a genuine willingness to wear multiple hats is essential
Requirements
- Bachelor's degree or higher in Biochemistry, Molecular Biology, Cell Biology, or a related life science field
- 4–6 years of hands-on laboratory experience, with demonstrated proficiency in antibody-based assay development and reagent characterization
- Direct experience with phage display or other affinity selection platforms
- Proficiency in ELISA, western blot, and at least one biophysical binding method (BLI or SPR)
- Practical experience with molecular cloning and mammalian cell culture
- Experience working within a LIMS or equivalent data management system
- Strong organizational skills and attention to detail, with the ability to manage multiple concurrent experiments
- Clear written and verbal communication skills; comfortable presenting data to diverse audiences
Preferred Skills
- Experience with fluorescence microscopy and/or cell-based imaging assays
- Experience with automated liquid handling and magnetic bead-based workflows
- Prior experience in a fast-paced biotech or startup research setting
We are looking for a skilled and motivated Senior Research Associate to join our affinity reagent discovery team. In this role, you will be a hands-on contributor to discovery campaigns including affinity reagent selection and characterization — from library panning through functional validation. You will provide both technical depth and the flexibility in a fast-moving, multi-project environment.
Responsibilities
- Execute and optimize phage display panning campaigns to identify and enrich antigen-specific affinity reagent clones
- Perform high-throughput screening and characterization using a variety of techniques, including ELISA, western blot, biolayer interferometry (BLI) and the Nautilus proteomics platform
- Carry out molecular cloning workflows supporting antibody reformatting, expression construct design, and recombinant protein production
- Culture mammalian cells (e.g., HEK293) for transient and stable protein expression
- Contribute to data recording, experiment tracking, and reagent management within a LIMS platform
- Present experimental results clearly and concisely to cross-functional teams
- Author and maintain SOPs, assay protocols, and other controlled documentation
- Take on dynamic task assignments across projects as team priorities evolve — a genuine willingness to wear multiple hats is essential
Requirements
- Bachelor's degree or higher in Biochemistry, Molecular Biology, Cell Biology, or a related life science field
- 4–6 years of hands-on laboratory experience, with demonstrated proficiency in antibody-based assay development and reagent characterization
- Direct experience with phage display or other affinity selection platforms
- Proficiency in ELISA, western blot, and at least one biophysical binding method (BLI or SPR)
- Practical experience with molecular cloning and mammalian cell culture
- Experience working within a LIMS or equivalent data management system
- Strong organizational skills and attention to detail, with the ability to manage multiple concurrent experiments
- Clear written and verbal communication skills; comfortable presenting data to diverse audiences
Preferred Skills
- Experience with fluorescence microscopy and/or cell-based imaging assays
- Experience with automated liquid handling and magnetic bead-based workflows
- Prior experience in a fast-paced biotech or startup research setting
About Nautilus Biotechnology
Nautilus Biotechnology is hiring for the senior research associate role. NewJob aggregates active openings directly from Nautilus Biotechnology's applicant tracking system, so this listing is current.
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