About this role
• Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Drug Metabolism, or related discipline • 12+ years of industry experience in DMPK within biotech or pharmaceutical settings • Demonstrated success advancing small molecule programs from discovery through IND • Deep expertise in ADME, human PK simulations, PK/PD modeling, and translational science • Experience working in or with early-stage companies, with comfort operating in resource-constrained, fast-paced environments • Strong track record of managing external CROs and consultants, and delivering high-quality data • Excellent communication skills, with the ability to influence cross-functional teams and leadership
DMPK Strategy & Scientific Leadership • Define and execute DMPK strategies across discovery and early development programs • Design and interpret in vitro and in vivo studies to guide compound optimization and candidate selection • Lead PK/PD modeling and exposure-response analyses to inform dosing strategies and translational plans • Provide scientific leadership in understanding ADME properties Cross-Functional Collaboration • Partner closely with medicinal chemistry, biology, and project teams to integrate DMPK insights into compound design and program decisions • Contribute to program strategy discussions, helping prioritize compounds and guide advancement decisions • Collaborate with toxicology and clinical teams to ensure alignment across preclinical and translational efforts External Vendor & CRO Management • Identify, select, and manage CRO partners and consultants to execute DMPK studies with high quality and efficiency • Oversee study design, data interpretation, and reporting from external partners • Ensure timelines, budgets, and deliverables are met across outsourced activities Regulatory & Development Contributions • Support IND-enabling activities, including preparation of DMPK sections for regulatory filings • Contribute to interactions with regulatory agencies as needed • Ensure DMPK data packages meet regulatory expectations and support clinical development plans
• You think like an owner—balancing scientific rigor with speed and pragmatism • You are both strategic and hands-on, comfortable zooming in and out as needed • You thrive in ambiguity and enjoy building as much as executing • You are collaborative, direct, and low-ego, with a focus on team success over individual recognition • You are motivated by the opportunity to make a meaningful impact for patients with serious disease
DMPK Strategy & Scientific Leadership • Define and execute DMPK strategies across discovery and early development programs • Design and interpret in vitro and in vivo studies to guide compound optimization and candidate selection • Lead PK/PD modeling and exposure-response analyses to inform dosing strategies and translational plans • Provide scientific leadership in understanding ADME properties Cross-Functional Collaboration • Partner closely with medicinal chemistry, biology, and project teams to integrate DMPK insights into compound design and program decisions • Contribute to program strategy discussions, helping prioritize compounds and guide advancement decisions • Collaborate with toxicology and clinical teams to ensure alignment across preclinical and translational efforts External Vendor & CRO Management • Identify, select, and manage CRO partners and consultants to execute DMPK studies with high quality and efficiency • Oversee study design, data interpretation, and reporting from external partners • Ensure timelines, budgets, and deliverables are met across outsourced activities Regulatory & Development Contributions • Support IND-enabling activities, including preparation of DMPK sections for regulatory filings • Contribute to interactions with regulatory agencies as needed • Ensure DMPK data packages meet regulatory expectations and support clinical development plans
• You think like an owner—balancing scientific rigor with speed and pragmatism • You are both strategic and hands-on, comfortable zooming in and out as needed • You thrive in ambiguity and enjoy building as much as executing • You are collaborative, direct, and low-ego, with a focus on team success over individual recognition • You are motivated by the opportunity to make a meaningful impact for patients with serious disease
About 5AM Ventures
5AM Ventures is hiring for the director/senior director, drug metabolism & pharmacokinetics role. NewJob aggregates active openings directly from 5AM Ventures's applicant tracking system, so this listing is current.
More jobs at 5AM Ventures →